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DG172 (dihydrochloride)
CAS No. 1361504-77-9
DG172 (dihydrochloride)( DG-172 dihydrochloride )
Catalog No. M21135 CAS No. 1361504-77-9
DG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | Get Quote |
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| 5MG | 50 | Get Quote |
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| 10MG | 87 | Get Quote |
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| 25MG | 177 | Get Quote |
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| 50MG | 290 | Get Quote |
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| 100MG | 470 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDG172 (dihydrochloride)
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NoteResearch use only, not for human use.
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Brief DescriptionDG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
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DescriptionDG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
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In VitroDG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM). DG172 (1 μM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 μM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.
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In Vivo——
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SynonymsDG-172 dihydrochloride
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPAR
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Research Area——
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Indication——
Chemical Information
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CAS Number1361504-77-9
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Formula Weight455.2
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Molecular FormulaC20H22BrCl2N3
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Purity>98% (HPLC)
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SolubilityH2O:14.29 mg/mL (31.39 mM; Need ultrasonic)
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SMILESCN1CCN(c2ccc(/C=C(\C#N)c3ccccc3Br)cc2)CC1.Cl.Cl
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Chemical Name(Z)-2-(2-bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lieber S et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J Med Chem. 2012 Mar 22;55(6):2858-68.
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